Clinicopathologic features and long-term outcomes of NUT midline carcinoma.

ABSTRACT:

Purpose

NUT midline carcinoma (NMC) is a poorly differentiated squamous cancer characterized by rearrangement of the NUT gene. Research advances have provided opportunities for targeted therapy in NMC, yet the clinical features of this rare disease have not been systematically characterized. We report on a large population of such patients to identify the disease characteristics and treatments, correlate them with outcome, and to consider clinical recommendations.

Experimental design

A clinical database was established using retrospective demographic and outcomes data available on all known cases of NMC. Questionnaires were completed by treating physicians. Pathologic, demographic, and clinical variables were assessed for 63 patients, the largest cohort of patients with NMC

SUBMITTER: Bauer DE 

PROVIDER: S-EPMC3473162 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature