Is serum phosphorus control related to parathyroid hormone control in dialysis patients with secondary hyperparathyroidism?

ABSTRACT:

Background

Elevated serum phosphorus (P) levels have been linked to increased morbidity and mortality in dialysis patients with secondary hyperparathyroidism (SHPT) but may be difficult to control if parathyroid hormone (PTH) is persistently elevated. We conducted a post hoc analysis of data from an earlier interventional study (OPTIMA) to explore the relationship between PTH control and serum P.

Methods

The OPTIMA study randomized dialysis patients with intact PTH (iPTH) 300-799 pg/mL to receive conventional care alone (vitamin D and/or phosphate binders [PB]; n=184) or a cinacalcet-based regimen (n=368). For patients randomized to conventional care, investigators were allowed flexibility in using a non-cinacalcet regimen (with no specific criteria for vitamin D analogue do

SUBMITTER: Frazao JM 

PROVIDER: S-EPMC3473247 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature