Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice.

ABSTRACT:

Background

Despite intensive research, malaria remains a major health concern for non-immune residents and travelers in malaria-endemic regions. Efficient adjunctive therapies against life-threatening complications such as severe malarial anaemia, encephalopathy, placental malaria or respiratory problems are still lacking. Therefore, new insights into the pathogenesis of severe malaria are imperative. Haemozoin (Hz) or malaria pigment is produced during intra-erythrocytic parasite replication, released in the circulation after schizont rupture and accumulates inside multiple organs. Many in vitro and ex vivo immunomodulating effects are described for Hz but in vivo data are limited. This study aimed to improve methods for Hz quantification in tissues and to investigate the accumula

SUBMITTER: Deroost K 

PROVIDER: S-EPMC3473299 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature