The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy.

ABSTRACT: Although molecular classification brings interesting insights into breast cancer taxonomy, its implementation in daily clinical care is questionable because of its expense and the information supplied in a single sample allocation is not sufficiently reliable. New approaches, based on a panel of small molecules derived from the global or targeted analysis of metabolic profiles of cells, have found a correlation between activation of de novo lipogenesis and poorer prognosis and shorter disease-free survival for many tumors. We hypothesized that the lipid content of breast cancer cells might be a useful indirect measure of a variety of functions coupled to breast cancer progression. Raman microspectroscopy was used to characterize metabolism of breast cancer cells with different degrees of m

SUBMITTER: Nieva C 

PROVIDER: S-EPMC3474759 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature