The risk of a second primary lung cancer after a first invasive breast cancer according to estrogen receptor status.

ABSTRACT:

Purpose

Lung cancers account for 5 % of second primary cancers after breast cancer. The low overall 5-year relative survival rate of lung cancer makes it a particularly concerning new malignancy for breast cancer survivors. It is unknown whether second lung cancer risk varies by estrogen receptor (ER) expression of the first breast cancer.

Methods

We evaluated second primary lung cancer risks using standardized incidence ratios (SIRs) (95 % confidence intervals (CIs)) among 222,148 one-year breast cancer survivors in the NCI-SEER Program registry database (1992-2008). Relative risks (RRs) and 95 % CIs for lung cancer following ER(-) compared with ER(+) breast cancer were estimated using Poisson regression, adjusted for age, year, and stage of breast cancer diagnosis, attaine

SUBMITTER: Schonfeld SJ 

PROVIDER: S-EPMC3474934 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature