A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb.

ABSTRACT:

Background

The ovine Major Histocompatibility Complex (MHC) harbors genes involved in overall resistance/susceptibility of the host to infectious diseases. Compared to human and mouse, the ovine MHC is interrupted by a large piece of autosome insertion via a hypothetical chromosome inversion that constitutes ~25% of ovine chromosome 20. The evolutionary consequence of such an inversion and an insertion (inversion/insertion) in relation to MHC function remains unknown. We previously constructed a BAC clone physical map for the ovine MHC exclusive of the insertion region. Here we report the construction of a high-density physical map covering the autosome insertion in order to address the question of what the inversion/insertion had to do with ruminants during the MHC evolution.

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SUBMITTER: Li G 

PROVIDER: S-EPMC3475007 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature