Genomic imprinting and genetic effects on muscle traits in mice.

ABSTRACT:

Background

Genomic imprinting refers to parent-of-origin dependent gene expression caused by differential DNA methylation of the paternally and maternally derived alleles. Imprinting is increasingly recognized as an important source of variation in complex traits, however, its role in explaining variation in muscle and physiological traits, especially those of commercial value, is largely unknown compared with genetic effects.

Results

We investigated both genetic and genomic imprinting effects on key muscle traits in mice from the Berlin Muscle Mouse population, a key model system to study muscle traits. Using a genome scan, we first identified loci with either imprinting or genetic effects on phenotypic variation. Next, we established the proportion of phenotypic variation

SUBMITTER: Karst S 

PROVIDER: S-EPMC3475036 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature