Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection.

ABSTRACT:

Background

Prosthetic joint infection (PJI) is an important failure mechanism of total joint arthroplasty (TJA). Here we examine whether the particular genetic variants can lead to increased susceptibility to PJI development.

Results

We conducted a genetic-association study to determine whether PJI could be associated with functional cytokine gene polymorphisms (CGP) influencing on innate immunity response. A case-control design was utilized and previously published criteria for PJI were included to distinguish between cases and control subjects with/without TJA. Six single nucleotide polymorphisms (SNPs) located in the genes for interleukin-1beta (SNP: IL1B-511, +3962), tumour necrosis factor alpha (TNF-308, -238) and interleukin-6 (IL6-174, nt565) were genotyped in 303 Cau

SUBMITTER: Stahelova A 

PROVIDER: S-EPMC3475038 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature