Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.

ABSTRACT:

Background

Gene expression profiling (GEP) in cells obtained from peripheral blood has shown that this is a very useful approach for biomarker discovery and for studying molecular pathogenesis of prevalent diseases. While there is limited literature available on gene expression markers associated with Chronic Obstructive Pulmonary Disease (COPD), the transcriptomic picture associated with critical respiratory illness in this disease is not known at the present moment.

Findings

By using Agilent microarray chips, we have profiled gene expression signatures in the whole blood of 28 COPD patients hospitalized with different degrees of respiratory compromise.12 of them needed of admission to the ICU, whilst 16 were admitted to the Respiratory Medicine Service. GeneSpring GX 11.0

SUBMITTER: Almansa R 

PROVIDER: S-EPMC3475085 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature