Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society.

ABSTRACT:

Objective

To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy.

Methods

Systematic review of relevant articles published between January 1985 and June 2007.

Results

It is highly probable that intrauterine first-trimester valproate (VPA) exposure has higher risk of major congenital malformations (MCMs) compared to carbamazepine and possible compared to phenytoin or lamotrigine. Compared to untreated WWE, it is probable that VPA as part of polytherapy and possible that VPA as monotherapy contribute to the development of MCMs. It is probable that antiepileptic drug (AED) polytherapy as compared to monotherapy regimens contributes to the development of MCMs and to reduced cognitive outcomes. For monotherapy, intr

SUBMITTER: Harden CL 

PROVIDER: S-EPMC3475194 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature