Cyclic Bis-1,3-dialkylpyridiniums from the sponge Haliclona sp.

ABSTRACT: Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

SUBMITTER: Lee Y 

PROVIDER: S-EPMC3475278 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature