Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study.

ABSTRACT:

Objectives and methods

The purpose of this study was to examine the incidence of mild cognitive impairment (MCI) and patterns of progression from incident MCI to dementia in 285 cognitively normal subjects (mean age, 78.9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011.

Results

Two hundred (70%) of the participants progressed to MCI; the age-adjusted incidence of MCI was 111.09 (95% confidence interval, 88.13-142.95) per 1,000 person-years. A total of 107 (53.5%) of the incident MCI subjects progressed to dementia. The mean time from MCI to dementia was 2.8 ± 1.8 years. Forty (20%) of the incident MCI cases had an "unstable" course: 19 (9.5%) converted to MCI and later returned to normal; 10 (5%) converted to MCI, to normal, and later ba

SUBMITTER: Lopez OL 

PROVIDER: S-EPMC3475628 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature