Indicators of amyloid burden in a population-based study of cognitively normal elderly.

ABSTRACT:

Objectives

Secondary prevention trials in subjects with preclinical Alzheimer disease may require documentation of brain amyloidosis. The identification of inexpensive and noninvasive screening variables that can identify individuals who have significant amyloid accumulation would reduce screening costs.

Methods

A total of 483 cognitively normal (CN) individuals, aged 70-92 years, from the population-based Mayo Clinic Study of Aging, underwent Pittsburgh compound B (PiB)-PET imaging. Logistic regression determined whether age, sex, APOE genotype, family history, or cognitive performance was associated with odds of a PiB retention ratio >1.4 and >1.5. Area under the receiver operating characteristic curve (AUROC) evaluated the discrimination between PiB-positive and -negative

SUBMITTER: Mielke MM 

PROVIDER: S-EPMC3475629 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature