High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination.

ABSTRACT:

Background

The mechanisms underlying smallpox vaccine-induced variations in immune responses are not well understood, but are of considerable interest to a deeper understanding of poxvirus immunity and correlates of protection.

Methods

We assessed transcriptional messenger RNA expression changes in 197 recipients of primary smallpox vaccination representing the extremes of humoral and cellular immune responses.

Results

The 20 most significant differentially expressed genes include a tumor necrosis factor-receptor superfamily member, an interferon (IFN) gene, a chemokine gene, zinc finger protein genes, nuclear factors, and histones (P ≤ 1.06E(-20), q ≤ 2.64E(-17)). A pathway analysis identified 4 enriched pathways with cytokine production by the T-helper 17 subset of

SUBMITTER: Haralambieva IH 

PROVIDER: S-EPMC3475634 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature