Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis.

ABSTRACT:

Objectives

To assess the efficacy of three different daily doses of acetazolamide in the prevention of acute mountain sickness and to determine the lowest effective dose.

Design

Systematic review and meta-analysis.

Data sources

Medline and Embase along with a hand search of selected bibliographies. No language restrictions were applied.

Study selection

Randomised controlled trials assessing the use of acetazolamide at 250 mg, 500 mg, or 750 mg daily versus placebo in adults as a drug intervention for the prophylaxis of acute mountain sickness. Included studies were required to state the administered dose of acetazolamide and to randomise participants before ascent to either acetazolamide or placebo. Two reviewers independently carried out the selection process.

SUBMITTER: Low EV 

PROVIDER: S-EPMC3475644 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature