Regulatory network structure as a dominant determinant of transcription factor evolutionary rate.

ABSTRACT: The evolution of transcriptional regulatory networks has thus far mostly been studied at the level of cis-regulatory elements. To gain a complete understanding of regulatory network evolution we must also study the evolutionary role of trans-factors, such as transcription factors (TFs). Here, we systematically assess genomic and network-level determinants of TF evolutionary rate in yeast, and how they compare to those of generic proteins, while carefully controlling for differences of the TF protein set, such as expression level. We found significantly distinct trends relating TF evolutionary rate to mRNA expression level, codon adaptation index, the evolutionary rate of physical interaction partners, and, confirming previous reports, to protein-protein interaction degree and regulatory in

SUBMITTER: Coulombe-Huntington J 

PROVIDER: S-EPMC3475661 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature