Genome analysis of Legionella pneumophila strains using a mixed-genome microarray.

ABSTRACT:

Background

Legionella, the causative agent for Legionnaires' disease, is ubiquitous in both natural and man-made aquatic environments. The distribution of Legionella genotypes within clinical strains is significantly different from that found in environmental strains. Developing novel genotypic methods that offer the ability to distinguish clinical from environmental strains could help to focus on more relevant (virulent) Legionella species in control efforts. Mixed-genome microarray data can be used to perform a comparative-genome analysis of strain collections, and advanced statistical approaches, such as the Random Forest algorithm are available to process these data.

Methods

Microarray analysis was performed on a collection of 222 Legionella pneumophila strains, which in

SUBMITTER: Euser SM 

PROVIDER: S-EPMC3475688 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature