Serum neutralizing activities from a Beijing homosexual male cohort infected with different subtypes of HIV-1 in China.

ABSTRACT: Protective antibodies play a critical role in an effective HIV vaccine; however, eliciting antibodies to block infection by viruses from diverse genetic subtypes remains a major challenge. As the world's most populous country, China has been under the threat of at least three major subtypes of circulating HIV-1 viruses. Understanding the cross reactivity and specificities of serum antibody responses that mediate broad neutralization of the virus in HIV-1 infected Chinese patients will provide valuable information for the design of vaccines to prevent HIV-1 transmission in China. Sera from a cohort of homosexual men, who have been managed by a major HIV clinical center in Beijing, China, were analyzed for cross-sectional neutralizing activities against pseudotyped viruses expressing Env ant

SUBMITTER: Zhang M 

PROVIDER: S-EPMC3475692 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature