Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis.

ABSTRACT: Genetic factors play an important role in determining the risk of multiple sclerosis (MS). The strongest genetic association in MS is located within the major histocompatibility complex class II region (MHC), but more than 50 MS loci of modest effect located outside the MHC have now been identified. However, the relative candidate genes that underlie these associations and their functions are largely unknown. We conducted a protein-protein interaction (PPI) analysis of gene products coded in loci recently reported to be MS associated at the genome-wide significance level and in loci suggestive of MS association. Our aim was to identify which suggestive regions are more likely to be truly associated, which genes are mostly implicated in the PPI network and their expression profile. From thr

SUBMITTER: Ragnedda G 

PROVIDER: S-EPMC3475710 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature