Cerebral vasospasm after sub-arachnoid hemorrhage as a clinical predictor and phenotype for genetic association study.

ABSTRACT:

Background

A typology of cerebral vasospasm has been proposed based on distinct clinical manifestations: delayed cerebral ischemia, symptomatic 'vasospasm', angiographic vasospasm, and transcranial Doppler vasospasm. We examined each distinct clinical manifestation in a nonparametric genetic association study.

Aims

The purpose of this study was to examine and compare each four distinct acute clinical manifestations and test its perspectives in genetic association studies.

Methods

Two hundred forty-five Caucasian patients with sub-arachnoid hemorrhage were evaluated for these four distinct clinical manifestations along with 906 600 single-nucleotide polymorphisms across the human genome.

Results

The four clinical manifestations were significantly associated with

SUBMITTER: Kim H 

PROVIDER: S-EPMC3475757 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature