Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View.

ABSTRACT:

Background

Phenome-Wide Association Studies (PheWAS) can be used to investigate the association between single nucleotide polymorphisms (SNPs) and a wide spectrum of phenotypes. This is a complementary approach to Genome Wide Association studies (GWAS) that calculate the association between hundreds of thousands of SNPs and one or a limited range of phenotypes. The extensive exploration of the association between phenotypic structure and genotypic variation through PheWAS produces a set of complex and comprehensive results. Integral to fully inspecting, analysing, and interpreting PheWAS results is visualization of the data.

Results

We have developed the software PheWAS-View for visually integrating PheWAS results, including information about the SNPs, relevant genes, phenot

SUBMITTER: Pendergrass SA 

PROVIDER: S-EPMC3476448 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature