Blood glucose control in type 1 diabetes with a bihormonal bionic endocrine pancreas.

ABSTRACT:

Objective

To test whether safe and effective glycemic control could be achieved in type 1 diabetes using a bihormonal bionic endocrine pancreas driven by a continuous glucose monitor in experiments lasting more than two days and including six high-carbohydrate meals and exercise as challenges to glycemic control.

Research design and methods

Six subjects with type 1 diabetes and no endogenous insulin secretion participated in two 51-h experiments. Blood glucose was managed with a bionic endocrine pancreas controlling subcutaneous delivery of insulin and glucagon with insulin pumps. A partial meal-priming bolus of insulin (0.035 units/kg/meal, then 0.05 units/kg/meal in repeat experiments) was administered at the beginning of each meal (on average 78 ± 12 g of carbohydrates pe

SUBMITTER: Russell SJ 

PROVIDER: S-EPMC3476884 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature