The Corynebacterium pseudotuberculosis in silico predicted pan-exoproteome.

ABSTRACT:

Background

Pan-genomic studies aim, for instance, at defining the core, dispensable and unique genes within a species. A pan-genomics study for vaccine design tries to assess the best candidates for a vaccine against a specific pathogen. In this context, rather than studying genes predicted to be exported in a single genome, with pan-genomics it is possible to study genes present in different strains within the same species, such as virulence factors. The target organism of this pan-genomic work here presented is Corynebacterium pseudotuberculosis, the etiologic agent of caseous lymphadenitis (CLA) in goat and sheep, which causes significant economic losses in those herds around the world. Currently, only a few antigens against CLA are known as being the basis of commercial and sti

SUBMITTER: Santos AR 

PROVIDER: S-EPMC3476999 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature