Integrative transcriptome analysis suggest processing of a subset of long non-coding RNAs to small RNAs.

ABSTRACT:

Background

The availability of sequencing technology has enabled understanding of transcriptomes through genome-wide approaches including RNA-sequencing. Contrary to the previous assumption that large tracts of the eukaryotic genomes are not transcriptionally active, recent evidence from transcriptome sequencing approaches have revealed pervasive transcription in many genomes of higher eukaryotes. Many of these loci encode transcripts that have no obvious protein-coding potential and are designated as non-coding RNA (ncRNA). Non-coding RNAs are classified empirically as small and long non-coding RNAs based on the size of the functional RNAs. Each of these classes is further classified into functional subclasses. Although microRNAs (miRNA), one of the major subclass of ncRNAs, have

SUBMITTER: Jalali S 

PROVIDER: S-EPMC3477000 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature