Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease in industrialized countries. The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from Acaudina molpadioides in fatty liver rats.

Methods

Male Wistar rats were randomly divided into four groups including normal control group, NAFLD model group, and two SCC-treated groups with SCC at 0.006% and 0.03% respectively. The fatty liver model was established by administration of 1% orotic acid (OA) to the rats. After 10d, serum and hepatic lipid levels were detected. And the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were also determined. Besides, to gain the potential mechanism, the change

SUBMITTER: Zhang B 

PROVIDER: S-EPMC3477080 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature