Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior.

ABSTRACT: Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed to associate contingent intravenous drug self-administration with specific patterns of gene expression in inbred mice differentially predisposed to the rewarding effects of morphine. In a Yoked-control paradigm, C57BL/6J mice showed clear morphine-reinforced behavior, whereas DBA/2J mice did not. Moreover, the Yoked-control paradigm revealed the powerful consequences of self-administration versus passive administration at the level of gene expression. Morphine self-administrat

SUBMITTER: Tapocik JD 

PROVIDER: S-EPMC3477247 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature