Fatigue before, during and after antiviral therapy of chronic hepatitis C: results from the Virahep-C study.

ABSTRACT:

Background & aims

Fatigue is the most frequent and often debilitating symptom of chronic hepatitis C. It is unclear whether successful therapy of hepatitis C leads to its clinical improvement. In the Virahep-C study, patients with hepatitis C virus (HCV) genotype 1 infection were treated with peginterferon alfa-2a and ribavirin for up to 48 weeks while undergoing assessment of viral kinetics and clinical symptoms.

Methods

Fatigue measurements were conducted, before, during and after therapy, as 'presence' (yes/no) and 'severity' (visual analog scale: 0-100mm). The clinical, histologic, and virologic features that correlated with the presence and degree of fatigue were assessed focusing upon changes associated with sustained virological response (SVR).

Results

At basel

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC3477271 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature