Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.

ABSTRACT:

Background & aims

GATA4, a zinc finger domain transcription factor, is critical for jejunal identity. Mice with an intestine-specific GATA4 deficiency (GATA4iKO) are resistant to diet-induced obesity and insulin resistance. Although they have decreased intestinal lipid absorption, hepatic de novo lipogenesis is inhibited. Here, we investigated dietary lipid-dependent and independent effects on the development of steatosis and fibrosis in GATA4iKO mice.

Methods

GATA4iKO and control mice were fed a Western-type diet (WTD) or a methionine and choline-deficient diet (MCDD) for 20 and 3 weeks, respectively. Functional effects of GATA4iKO on diet-induced liver steatosis were investigated.

Results

WTD-but not MCDD-fed GATA4iKO mice showed lower hepatic concentrations of trig

SUBMITTER: Patankar JV 

PROVIDER: S-EPMC3477492 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature