Prognosis of medullary breast cancer: analysis of 13 International Breast Cancer Study Group (IBCSG) trials.

ABSTRACT:

Background

To evaluate whether medullary breast cancer has a better prognosis compared with invasive ductal tumors.

Methods

Among 12,409 patients, 127 were recorded as invasive medullary tumors and 8096 invasive ductal tumors. Medullary and ductal invasive tumors were compared with regard to stage, age at diagnosis, grade, hormone receptor status, peritumoral vascular invasion, and local and systemic treatment. Pattern of relapse, distant recurrence-free interval (DRFI), and overall survival (OS) were determined for both histological groups. Two cohorts were investigated: a full cohort including the pathologist-determined medullary histology without regard to any other tumor features and a cohort restricted to patients with ER-negative grade 3 tumors.

Results

Fourteen

SUBMITTER: Huober J 

PROVIDER: S-EPMC3477879 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature