Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).

ABSTRACT:

Background

Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction.

Patients and methods

A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10,947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4).

Results

The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagno

SUBMITTER: Duell EJ 

PROVIDER: S-EPMC3477881 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature