Identification of common carp (Cyprinus carpio) microRNAs and microRNA-related SNPs.

ABSTRACT:

Background

MicroRNAs (miRNAs) exist pervasively across viruses, plants and animals and play important roles in the post-transcriptional regulation of genes. In the common carp, miRNA targets have not been investigated. In model species, single-nucleotide polymorphisms (SNPs) have been reported to impair or enhance miRNA regulation as well as to alter miRNA biogenesis. SNPs are often associated with diseases or traits. To date, no studies into the effects of SNPs on miRNA biogenesis and regulation in the common carp have been reported.

Results

Using homology-based prediction combined with small RNA sequencing, we have identified 113 common carp mature miRNAs, including 92 conserved miRNAs and 21 common carp specific miRNAs. The conserved miRNAs had significantly higher expres

SUBMITTER: Zhu YP 

PROVIDER: S-EPMC3478155 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature