Neglected tropical diseases: survey and geometry of randomised evidence.

ABSTRACT:

Objective

To assess the quantity and distribution of evidence from randomised controlled trials for the treatment of the major neglected tropical diseases and to identify gaps in the evidence with network analysis.

Design

Systematic review and network analysis.

Data sources

Cochrane Central Register of Controlled Trials and PubMed from inception to 31 August 2011.

Study selection

Randomised controlled trials that examined treatment of 16 neglected tropical diseases or complications thereof published in English, French, Spanish, Portuguese, German, or Dutch.

Results

We identified 971 eligible randomised trials. Leishmaniasis (184 trials, 23,039 participants) and geohelminth infections; 160 trials, 46,887 participants) were the most studied, while dracuncu

SUBMITTER: Kappagoda S 

PROVIDER: S-EPMC3478233 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature