The discovery of population differences in network community structure: new methods and applications to brain functional networks in schizophrenia.

ABSTRACT: The modular organization of the brain network can vary in two fundamental ways. The amount of inter- versus intra-modular connections between network nodes can be altered, or the community structure itself can be perturbed, in terms of which nodes belong to which modules (or communities). Alterations have previously been reported in modularity, which is a function of the proportion of intra-modular edges over all modules in the network. For example, we have reported that modularity is decreased in functional brain networks in schizophrenia: There are proportionally more inter-modular edges and fewer intra-modular edges. However, despite numerous and increasing studies of brain modular organization, it is not known how to test for differences in the community structure, i.e., the assignment

SUBMITTER: Alexander-Bloch A 

PROVIDER: S-EPMC3478383 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature