Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma.

ABSTRACT: NECL-5 is involved in regulating cell-cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant transformation was previously described. It has been reported that transformation of melanocytes is associated with altered expression of adhesion molecules suggesting the potential involment of NECL-5 in melanoma development and prognosis. To shed light on this issue, the expression and the role of NECL-5 in melanoma tissues was investigated by bioinformatic and molecular approaches. NECL-5 was up-regulated both at the mRNA and the protein levels in WM35, M14 and A375 cell lines compared with normal melanocytes. A subsequent analysis in primary and metastatic melanoma specimens

SUBMITTER: Bevelacqua V 

PROVIDER: S-EPMC3478464 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature