Total chemical synthesis of biologically active vascular endothelial growth factor.

ABSTRACT: Efficient access: the 204-residue covalent-dimer vascular endothelial growth factor with full mitogenic activity was prepared from three unprotected peptide segments by one-pot native chemical ligations. The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography.

SUBMITTER: Mandal K 

PROVIDER: S-EPMC3478761 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature