Pilot study: association of traditional and genetic risk factors and new-onset diabetes mellitus following kidney transplantation.

ABSTRACT:

Introduction

New-onset diabetes mellitus, which occurs after kidney transplant and type 2 diabetes mellitus (T2DM), shares common risk factors and antecedents in impaired insulin secretion and action. Several genetic polymorphisms have been shown to be associated with T2DM. We hypothesized that transplant recipients who carry risk alleles for T2DM are "tipped over" to develop diabetes mellitus in the posttransplant milieu.

Methods

We investigated the association of genetic and traditional risk factors present before transplantation and the development of new-onset diabetes mellitus after kidney transplantation (NODAT). Markers in 8 known T2DM-linked genes were genotyped using either the iPLEX assay or allelic discrimination (AD)-PCR in the study cohort testing for associatio

SUBMITTER: Chakkera HA 

PROVIDER: S-EPMC3478878 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature