Chlamydia trachomatis protein GrgA activates transcription by contacting the nonconserved region of σ66.

ABSTRACT: The bacterial RNA polymerase holoenzyme consists of a catalytic core enzyme in complex with a σ factor that is required for promoter-specific transcription initiation. Primary, or housekeeping, σ factors are responsible for most of the gene expression that occurs during the exponential phase of growth. Primary σ factors share four regions of conserved sequence, regions 1-4, which have been further subdivided. Many primary σ factors also contain a nonconserved region (NCR) located between subregions 1.2 and 2.1, which can vary widely in length. Interactions between the NCR of the primary σ factor of Escherichia coli, σ(70), and the β' subunit of the E. coli core enzyme have been shown to influence gene expression, suggesting that the NCR of primary σ factors represents a potential target fo

SUBMITTER: Bao X 

PROVIDER: S-EPMC3479454 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature