Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by symptoms of inattention and hyperactivity/impulsivity, but there is increased recognition of a motivation deficit too. This neuropathology may reflect dysfunction of both attention and reward-motivation networks.

Methods

To test this hypothesis, we compared the functional connectivity density between 247 ADHD and 304 typically developing control children from a public magnetic resonance imaging database. We quantified short- and long-range functional connectivity density in the brain using an ultrafast data-driven approach.

Results

Children with ADHD had lower connectivity (short- and long-range) in regions of the dorsal attention (superior parietal cortex) and default-mode (precu

SUBMITTER: Tomasi D 

PROVIDER: S-EPMC3479644 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature