Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation.

ABSTRACT: Obesity is associated with a low-grade chronic inflammation state. As a consequence, adipose tissue expresses pro-inflammatory cytokines that propagate inflammatory responses systemically elsewhere, promoting whole-body insulin resistance and consequential islet β-cell exhaustation. Thus, insulin resistance is considered the early stage of type 2 diabetes. However, there is evidence of obese individuals that never develop diabetes indicating that the mechanisms governing the association between the increase of inflammatory factors and type 2 diabetes are much more complex and deserve further investigation. We studied for the first time the differences in insulin signalling and inflammatory pathways in blood and visceral adipose tissue (VAT) of 20 lean healthy donors and 40 equal morbidly o

SUBMITTER: Barbarroja N 

PROVIDER: S-EPMC3480488 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature