Vitamin D deficiency, smoking, and lung function in the Normative Aging Study.

ABSTRACT:

Rationale

Vitamin D has immunomodulatory and antiinflammatory effects that may be modified by cigarette smoke and may affect lung function.

Objectives

To examine the effect of vitamin D deficiency and smoking on lung function and lung function decline.

Methods

A total of 626 men from the Normative Aging Study had 25-hydroxyvitamin D levels measured at three different times between 1984 and 2003 with concurrent spirometry. Vitamin D deficiency was defined as serum level ≤ 20 ng/ml. Statistical analysis was performed using multivariable linear regression and mixed effects models.

Measurements and main results

In the overall cohort, there was no significant effect of vitamin D deficiency on lung function or on lung function decline. In both cross-sectional and lon

SUBMITTER: Lange NE 

PROVIDER: S-EPMC3480523 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature