Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.

ABSTRACT:

Rationale

Acute lung injury (ALI) is an important cause of morbidity and mortality, with no currently effective pharmacological therapies. Neutrophils have been specifically implicated in the pathogenesis of ALI, and there has been significant research into the mechanisms of early neutrophil recruitment, but those controlling the later phases of neutrophil emigration that characterize disease are poorly understood.

Objectives

To determine the influence of peripheral blood monocytes (PBMs) in established ALI.

Methods

In a murine model of LPS-induced ALI, three separate models of conditional monocyte ablation were used: systemic liposomal clodronate (sLC), inducible depletion using CD11b diphtheria toxin receptor (CD11b DTR) transgenic mice, and antibody-dependent ablat

SUBMITTER: Dhaliwal K 

PROVIDER: S-EPMC3480527 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature