Effect of vitamin D and inhaled corticosteroid treatment on lung function in children.

ABSTRACT:

Rationale

Low vitamin D levels are associated with asthma and decreased airway responsiveness. Treatment with inhaled corticosteroids improves airway responsiveness and asthma control.

Objectives

To assess the effect of vitamin D levels on prebronchodilator FEV(1), bronchodilator response, and responsiveness to methacholine (PC(20), provocative concentration of methacholine producing a 20% decline in FEV(1)) in patients with asthma treated with inhaled corticosteroids.

Methods

We measured 25-hydroxyvitamin D levels in the serum of children with persistent asthma at the time of enrollment in the Childhood Asthma Management Program. We divided subjects into the vitamin D sufficiency (>30 ng/ml), insufficiency (20-30 ng/ml), and deficiency (<20 ng/ml) groups. Covariates

SUBMITTER: Wu AC 

PROVIDER: S-EPMC3480528 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature