Variation in PTX3 is associated with primary graft dysfunction after lung transplantation.

ABSTRACT:

Rationale

Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis.

Objectives

Our goal was to test whether variants in the gene encoding PTX3 are risk factors for PGD.

Methods

We performed a candidate gene association study in recipients from the multicenter, prospective Lung Transplant Outcomes Group cohort enrolled between July 2002 and July 2009. The primary outcome was International Society for Heart and Lung Transplantation grade 3 PGD within 72 hours of transplantation. Targeted genotyping of 10 haplotype-tagging PTX3 single-nucleotide polymorphisms (SNPs) was performed in lung transpla

SUBMITTER: Diamond JM 

PROVIDER: S-EPMC3480532 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature