Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events.

ABSTRACT:

Background

Renal function is a strong predictor of adverse events in heart failure. Current renal function measures are imperfect, and cystatin C (CysC) is promoted as a better marker of glomerular filtration rate. This study compares the prognostic use of CysC and derived glomerular filtration rate estimates with other measures of renal function in patients with chronic heart failure.

Methods and results

We measured serum CysC levels in 823 patients with heart failure undergoing coronary angiography with follow-up of major adverse cardiovascular events (death, myocardial infarction, stroke). CysC levels strongly correlated with creatinine (r=0.73), blood urea nitrogen (r=0.70), and estimated glomerular filtration rate by the 4-variable modification of diet in renal disease

SUBMITTER: Dupont M 

PROVIDER: S-EPMC3480661 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature