Invasiveness of mouse embryos to human ovarian cancer cells HO8910PM and the role of MMP-9.

ABSTRACT:

Background

Our previous work found that mouse embryos could invade malignant cancer cells. In the process of implantation, embryo trophoblast cells express matrix metalloproteinases and the invasive ability of trophoblast cells is proportional to matrix metalloproteinase-9 protein expression. So the purpose of this study is to observe the effects of mouse embryos on human ovarian cancer cells in the co-culture environment in vitro and explore the possible mechanism of matrix metalloproteinase-9.

Methods

Several groups of human ovarian cancer cells HO8910PM were co-cultured with mouse embryos for different time duration, after which the effects of mouse embryos on morphology and growth behavior of HO8910PM were observed under the light microscope real-time or by H.E staining.

SUBMITTER: Ding X 

PROVIDER: S-EPMC3480839 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature