Transcriptome classification reveals molecular subtypes in psoriasis.

ABSTRACT:

Background

Psoriasis is an immune-mediated disease characterised by chronically elevated pro-inflammatory cytokine levels, leading to aberrant keratinocyte proliferation and differentiation. Although certain clinical phenotypes, such as plaque psoriasis, are well defined, it is currently unclear whether there are molecular subtypes that might impact on prognosis or treatment outcomes.

Results

We present a pipeline for patient stratification through a comprehensive analysis of gene expression in paired lesional and non-lesional psoriatic tissue samples, compared with controls, to establish differences in RNA expression patterns across all tissue types. Ensembles of decision tree predictors were employed to cluster psoriatic samples on the basis of gene expression patterns and

SUBMITTER: Ainali C 

PROVIDER: S-EPMC3481433 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature