Boolean modeling and fault diagnosis in oxidative stress response.

ABSTRACT:

Background

Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress response mechanism can induce aberrant cellular behavior leading to diseases such as neurodegenerative disorders and cancer. Thus, understanding the normal signaling present in oxidative stress response pathways and determining possible signaling alterations leading to disease could provide us with useful pointers for therapeutic purposes. Using knowledge of oxidative stress response pathways from the literature, we developed a Boolean network model whose simulated behavior is

SUBMITTER: Sridharan S 

PROVIDER: S-EPMC3481480 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature