In Silico Identification of Potential American Cockroach (Periplaneta americana) Allergens.

ABSTRACT:

Background

Cockroaches have been recognized as a powerful indoor allergen. Cockroach allergy can be a major factor in serious asthma and nasal allergy. Bioinformatics tools have been developed to identify potential allergens. The present study was conducted to identify potential allergens in Periplaneta americana (Linnaeus).

Methods

The study focused on the identification of potential allergens among the characterized proteins of P. americana using web-based and publicly available allergen prediction tools that follow the FAO/WHO guidelines for prediction of allergenic proteins. P. americana protein sequences were retrieved from UniProtKB. The sequences obtained were analyzed using AlgPred. The potential allergens obtained were further analyzed by SDAP for confirmation.

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SUBMITTER: Ahmed A 

PROVIDER: S-EPMC3481629 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature