Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.

ABSTRACT:

Purpose

Adipose tissue contains a population of tumor-tropic mesenchymal progenitors, termed adipose stromal cells (ASC), which engraft in neighboring tumors to form supportive tumor stroma. We hypothesized that intra-abdominal visceral adipose tissue may contain a uniquely tumor-promoting population of ASC to account for the relationship between excess visceral adipose tissue and mortality of intra-abdominal cancers.

Experimental design

To investigate this, we isolated and characterized ASC from intra-abdominal omental adipose tissue (O-ASC) and characterized their effects on endometrial cancer progression as compared with subcutaneous adipose-derived mesenchymal stromal cells (SC-ASC), bone marrow-derived mesenchymal stromal cells (BM-MSC), and lung fibroblasts. To model c

SUBMITTER: Klopp AH 

PROVIDER: S-EPMC3481843 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature