Descriptive epidemiology of non-syndromic complete atrioventricular canal defects.

ABSTRACT:

Background

Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non-syndromic CAVC. Risk factors for non-syndromic CAVC have not been well established.

Methods

To assess the relationship between risk for non-syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 non-syndromic cases with CAVC.

Results

Significant associations were observed between non-syndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR

SUBMITTER: Agopian AJ 

PROVIDER: S-EPMC3482101 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature